The Environmental Protection Agency (EPA) is announcing the availability of a final document titled, ``Final Integrated Science Assessment for Oxides of Nitrogen, Oxides of Sulfur, and Particulate Matter--Ecological Criteria'' (EPA/600/R-20/278). The document was prepared by the Center for Public Health and Environmental Assessment (CPHEA) within EPA's Office of Research and Development (ORD) as part of the review of the secondary (welfare-based) national ambient air quality standards (NAAQS) for oxides of nitrogen, oxides of sulfur, and particulate matter. This ISA represents an update of the 2008 Integrated Science Assessment for Oxides of Nitrogen and Sulfur-- Ecological Criteria (EPA/600/R-08/082F) and the 2009 Integrated Science Assessment for Particulate Matter (EPA/600/AR-08/139F). The ISA, in conjunction with additional technical and policy assessments, provides the basis for EPA's decisions on the adequacy of the current NAAQS and the appropriateness of possible alternative standards.